Walters expects to leave hospital soon

NEW YORK (AP) ? Barbara Walters says she expects to be home from the hospital soon after taking a spill at a Saturday night party at the British ambassador's home in Washington.

The veteran ABC newswoman thanked people who expressed concern in a statement read Monday on "The View."

She says she's running a low-grade fever and doctors don't want to release her until her temperature is normal. She says things are going in the right direction and she expects to be home soon.

Her colleagues at "The View" wished her well on the air, although comic Joy Behar couldn't resist a joke.

Behar urged Walters to get well and to "lay off the Grey Goose" vodka.

Source: http://news.yahoo.com/walters-expects-leave-hospital-soon-185635611.html

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A Healthy Diet Colin Kaepernick Jersey Is Essential For Appropriate ...

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Immune system molecule with hidden talents

Wednesday, January 23, 2013

Dendritic cells, or DCs for short, perform a vital role for the immune system: They engulf pathogens, break them down into their component parts, and then display the pieces on their surface. This in turn signals other immune cells capable of recognizing these pieces to help kick-start their own default program for fighting off the invaders. In order to do their job, the DCs are dependent upon the support from a class of immune system molecules, which have never before been associated with dendritic cells: antibodies, best known for their role in vaccinations and diagnostics. Now, scientists at the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH) were able to show that antibodies are essential for dendritic cell maturation. The researchers' findings have been published in the renowned scientific journal, Proceedings of the National Academy of Sciences (PNAS).

The human immune system is made up of some half a dozen different cell types that are all working in tandem. Team work is key since each cell type has a single unique job to perform, which is central to its ability to help defend the body against invaders and ward off disease. If one of these players is taken out of commission, the entire system is thrown out of whack.

This is precisely what Dr. Siegfried Weiss, head of HZI Department of Molecular Immunology, and his team of researchers observed when they looked at immunodeficient mice. "Our 'RAG' mice are lacking adaptive, or acquired immunity," explains Weiss. "Basically, what this means is they are missing their antibody-producing B cells, among others."

The dendritic cells belong to a different branch of the immune system - innate immunity, which, although far less pliable, is capable of a fairly rapid response. Which is why these cells should not be affected by a defect in acquired immunity. Still, the scientists noticed that DCs obtained from this particular murine strain were not working properly - their maturation process was faulty and instead of breaking down a pathogen into small pieces, they ended up destroying the pathogen altogether. "The broken down pieces are called antigens. Presenting antigen is the dendritic cells' main job," explains Dr. Natalia Zietara, one of the scientists who worked on this study. "In fact, it is one of the most important points of intersection between the immune system's innate and acquired branches. If it goes missing, any subsequent immune responses don't ever get triggered," adds her colleague, Dr. Marcin Lyszkiewicz. The cells' normally highly precise interplay comes to a standstill and the acquired immune response becomes largely ineffective at a targeted defense against invading pathogens.

Starting with this observation, the immunologists were interested in identifying the cause behind the defect in the DCs' function. To this end, they initially examined the dendritic cells' surface markers for any potential deviation from the norm - albeit to no avail. Only once they began studying the transcriptome, the sum total of genes that are active in the cells that were being examined, the researchers found what it was they were looking for: The activity of a select few genes, among them those encoding a family of receptors capable of binding antibodies, had been altered. Through a series of subsequent experiments, the researchers were able to show that it was these very molecules, which stimulated dendritic cell maturation.

Antibodies, also called immunoglobulins, are proteins made by B cells. Their normal job is one of neutralizing toxins or viruses and labeling bacteria for destruction by other immune cells. The concept of vaccination is based on artificially prompting the organism to make antibodies, which, at a later stage - specifically, upon contact with the actual pathogen - helps the body ward off disease. Until now, this new role for antibodies was completely unknown. "We had no idea that B cells and dendritic cells use immunoglobulins to communicate with each other. It just goes to show you how complex the immune system really is and how we are a long way from truly grasping the full scope of its complexity," says Dr. Andreas Krueger, head of the Lymphocyte Biology research group at the MHH's Institute of Immunology. In a way, you might say the researchers discovered a 'hidden talent' of antibodies.

Natalia Zietara and Marcin Lyszkiewicz are both named as the study's primary co-authors. They initially kicked off their investigation during the time of their doctoral work in Siegfried Weiss' department at HZI and, upon earning their PhDs, transferred to the MHH where they were able to see the project to its conclusion working in Andreas Krueger's lab. According to Weiss, "this is a prime example of a genuine scientific collaborative." Two other HZI research groups, along with scientists from Freiburg University and the Max Planck Institute of Immunobiology and Epigenetics, were also part of the research project.

###

Helmholtz Centre for Infection Research: http://www.helmholtz-hzi.de/en

Thanks to Helmholtz Centre for Infection Research for this article.

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Source: http://www.labspaces.net/126408/Immune_system_molecule_with_hidden_talents

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Ridgerock School of Secondary Education

Two schools in the town of Ridgerock have merged and now the war is being held under one roof. With conflicting personalities can all the students get along to save their educations?

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.

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Could I please reserve a girl from Ridgerock High?

This RP looks really good! It's like my school, aha.

"Light can be found in even the darkest places if one only remembers to turn on the lights." - Albus Dumbledore.

MissBrightside_

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Yes your reservation has been placed.

DarkCookie97

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I would like to reserve a girl from Ridgerock High and a guy for Ridgerrock Academy please!

Miss_Dreamer

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I'm going to be leaving this Saturday for a 10 day vacation but if that's alright with you I'd like to reserve a girl from Ridgerock High!

akjadestar

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I'd like to reserve a girl from the academy and a girl from the school, please ^-^

The Writer's Voice

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E-Commerce Platform Gumroad Adds New Publishing Features, Says Some Authors Have Made $100K+

Gumroad, the Kleiner Perkins-backed startup that allows you to sell anything through a simple link, is announcing some additions to its publishing program today, while also sharing some of its early success stories. Ryan Delk, who leads the company's growth and partnership efforts, said traditional publishing is "still operating on economics and strategies that were invented 20 years ago." Specifically, he said, "The power has shifted ? it no longer lies with these aggregators and marketplaces, but with individuals and their existing platforms." That's the kind of shift that Gumroad (with its ethos of "share and sell the stuff you make directly to your audience") is trying to take advantage of, in this case giving authors an easy way to sell to fans directly. Delk added that publishing is one of the company's "biggest verticals."

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Kate Upton Super Bowl Ad Teaser: Model Washes Mercedes in Slow Motion!

Source: http://www.thehollywoodgossip.com/2013/01/kate-upton-super-bowl-ad-teaser-washing-a-mercedes-in-slow-motio/

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Please Let This Leaked 6.4-Inch 1080p Sony Phone Be A Joke

According to a forum posting on Chinese site Digi-wo, Sony may have a 6.44-inch 1080 device in the works. We don't know much else about the alleged device, other than that it's said to have no capacitive navigation buttons and a very thin bezel. It also has no Xperia branding, but the Xperia Z's branding is on the back of the device, so that's a wash. Obviously, this is completely unconfirmed, and even if it is real, it may be a Walkman or some sort of mini-tablet. Or, it could be a phablet, and the competition between manufacturers to offer the biggest, most awesome screen has officially become entirely absurd.

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