Wednesday, February 29, 2012

How Multiple Owners Can Take Title ? Tampa Bay Real Estate Law ...

There are many ways in which multiple owners can take title to Florida real property. Some of them include:

1. Tenants in Common. The simplest type of common ownership. Each person would own a quarter of the property and there would be no survivorship.

2. Combination of Tenancy by the Entirety and Tenancy in Common. The two couples, both a tenants by the entirety, could take title as tenants in common. Both couples would own an undivided one half of the property.

3. Joint Tenants with the Right of Survivorship. In this type of ownership, the last of the four owners to die would own all of the property. There are limitations on the shares that the owners can hold in this type of common ownership.

4. Florida Land Trust. Section 681.079 of the Florida Statutes creates a special type of trust for land ownership that is only available in Florida and a few other states.

5. Estate Planning Trust. If the northerners have inter vivos trusts established as part of their estate planning, the trustees to these trusts can take title to Florida property.

6. Enhanced Life Estate. This is a special type of life estate that is recognized in Florida, but not in all other states. It is useful if they want to pass title on to descendants without going through probate but still want to retain control of the property.

7. Limited Liability Company (LLC). An LLC can be a good option if they are concerned about limiting their liability or if they want to establish special requirements about the way the property will be handled.

8. Partnership. One of the simplest types of common ownership. It can be structured to accommodate the special needs of the partners.

9. Limited Liability Partnership (LLP). An LLP combines the simplicity of a partnership with the liability protection of an LLC.

10. Corporation (either S or C). For federal income tax reasons, title to real property should NEVER be taken in any type of corporation if it can be avoided.

All of these types of ownership (except the corporation) are viable options for ownership of Florida real estate. Only a lawyer has the experienced and training to advise clients on which type of ownership would be best for them.

Marshall C. Deason, Jr.
Board Certified Real Estate Lawyer
Tampa Bay Business Law, LLP
601 Bayshore Boulevard
Suite 150
Tampa, Florida 33606
813-434-4800
marshall@tampabaybusinesslaw.com

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February 27, 2012 - Posted by deasonlaw | Tampa Bay Real Estate Market

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Source: http://tampabayrealestatelaw.wordpress.com/2012/02/27/how-multiple-owners-can-take-title/

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Motorola Mobility making it easy for business owners to switch to Android with new trade-in program

Motorola Mobility

Motorola Mobility has been making some big moves when it comes to capturing business customers and ensuring they become Android users. Their latest efforts are set to kick off on Feb. 28th as noted in their press release:

Starting tomorrow, the company will be offering up to $200 cash back for a consumer’s old device when a Motorola Business Ready smartphone is purchased, providing an instant online quote, pre-paid shipping label, and payment within four to six weeks of receipt. In addition, Motorola Mobility will be offering the MotoAssist™ IT service to give business users access to IT professionals who can help set up accounts, transfer contacts seamlessly, and even work directly with corporate IT departments.

We've seen a rather large push for Android in the business sector recently and if Motorola can continue to offer new devices while saving business owners money it has the potential to put them in a very good place. The full press release is past the break for you all or you can check out the source link below for more details.

Source: Motorola

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/XG7AloDwySM/story01.htm

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Tuesday, February 28, 2012

Obama urges governors to boost education funding (The Arizona Republic)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/205307661?client_source=feed&format=rss

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School Arts - the Art Education Magazine for K-12 Art Educat ...

School Arts - the Art Education Magazine for K-12 Art Educat 4.8 out of 5 based on 4 ratings. 0 user reviews

Technorati Tags: Arts, Educat, Education, K-12, Magazine, School

Tags: Arts, Educat, Education, K-12, Magazine, School

Source: http://www.ikusa.net/2012/02/school-arts-the-art-education-magazine-for-k-12-art-educat/

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final phase fat loss ? Muscle Building and Fitness Trumps Simple ...

Whether you?re a man or a woman, it is important for your overall health and well-being that you concentrate on building muscle and fitness. Many people say I talk to they really want to build muscle and improve fitness, but are afraid to lift weights because they do not want to bulk up and look like a bodybuilder. They assume that the muscle will weigh more included. This is not the case.

Want to be fit and stay fit, you must build muscle fitness.Final Phase Fat Loss Faulty thinking that you lose as a professional bodybuilder is ridiculous and shows a profound ignorance of how the dedication and efforts in achieving this aspect of bodybuilding. These muscles do not appear after a few bench presses. It takes years and focus on the muscle groups that define the bodybuilders to build.

A myth of the bodybuilding and fitness humor that was his, it would not be so ridiculous is that muscle weighs more than fat. Obviously, a book, a book if it is fat or muscle. The difference between the two is that a pound of muscle up much less volume than a pound of fat. Muscle is more dense. If you have ten pounds of new muscle in your body, you have less of an increase in body size than you would with ten new pounds of fat. Fat takes up more room.
final phase fat loss Some people who tried their level of fitness and muscle have thin physique, have in fact no more than they discovered that there was a weight gain associated with their exercises, due to the increased muscle mass. They saw the increase in weight, where not more than a problem. They did not understand that their exercise had a lot of unhealthy body fat removed and replaced it with muscle power of virtue, and he had also left the thinnest and trim as they were before. Do not rush with cardio exercises to burn the extra weight of strength training, it is a good weight, not body fat.

Source: http://articlebro.com/2012/health-fitness/final-phase-fat-loss-muscle-building-and-fitness-trumps-simple-weight-loss-2/

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Monday, February 27, 2012

Taylor Kitsch Brings Exclusive 'John Carter' Clip To 'MTV First'

Tune in to MTV at 7:56 p.m. on Thursday, March 1, to see the sneak peek, and then watch Kitsch answer your questions on MTV.com.
By Kara Warner


Taylor Kitsch in "John Carter"
Photo: Disney

Taylor Kitsch is making a major leap from small-screen sports hero Tim Riggins in "Friday Night Lights," to potential blockbuster action-movie star via three big-budget films: Disney's sci-fi fantasy "John Carter," "Battleship" and crime thriller "Savages." And just before he officially catapults to superstar status, he's answering your questions.

On Thursday, March 1, Kitsch will sit down with MTV News' Josh Horowitz to present a clip from his upcoming action adventure during "MTV First: John Carter." At 7:56 p.m. ET on MTV, Kitsch will introduce the clip, followed by a 30-minute interview that will continue on MTV.com, where Kitsch will answer more of your questions.

To get your question answered, all you have to do is send it via Twitter, using @MTVNews and the hashtag #MTVFirst or #AskKitsch.

"MTV First" will give you a chance to see a never-before-seen clip from "John Carter," eight days before it hits theaters on March 9.

Set on the mysterious and exotic planet of Barsoom (Mars), "John Carter" is the story of a war-weary former military captain (Kitsch), who is inexplicably transported to Mars, where he becomes reluctantly embroiled in a conflict of epic proportions among the inhabitants of the planet, including Tars Tarkas (Willem Dafoe) and the captivating Princess Dejah Thoris (Lynn Collins).

"There's kind of that stigma with big movies that it's just action," Kitsch told MTV News."But with this, it's really just the core of this guy and his journey of reinventing himself and finding himself again."

"John Carter" is based on Edgar Rice Burroughs' classic novel "John Carter of Mars." The film will be released on March 9 in digital 3-D and IMAX 3-D.

Catch Taylor Kitsch Thursday, March 1, on MTV at 7:56 p.m. ET, when he'll debut an exclusive, never-before-seen clip from "John Carter." Then head over to MTV.com for our 30-minute chat with Rudd and Aniston.

Related Videos

Source: http://www.mtv.com/news/articles/1680054/taylor-kitsch-john-carter.jhtml

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Bored and looking to do a few requests.

Eh... after spending all day not finishing much of anything art-wise, sure, requesting stuff from someone else sounds nice. xD I don't have anything specific I want though, so you can draw whoever ye fancy, if anyone at all.

There's the snark flirtster, self-proclaimed sexy-pants.
The grouchy hardass black guy.
The colorful gullible alien girl.
The ancient bird failing miserably at fitting into modern times.
Ahhhm, I have more ref for each buddy, I think, scattered about in OOC threads. I can fetch 'em if necessary.

As with all requestees, YOU ARE LOVELY! Keep drawin'. :) <3 (Also, teach me how to color like that lovely second one, urrrgh...!)

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/9jmSVOiNcvI/viewtopic.php

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Luxury House Decorating Ideas 2012 | Noahs Window

interior designThis a selection ofLuxury House, Interior Decoration and Decor ideas also available on http://www.weplan.com.au
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design
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before and after
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Interior Designer
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Rebecca Robeson
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Duration : 0:5:49

This entry was posted in Interior Design and tagged 2010, bathroom, bedroom, before and after makeover, decor, decorating, designer, environment, HD, home, ideas, IKEA, interior, interior design, interior designs, kitchen, living room, makeovers, modern, redecorate, remodel, remodeling, room, spa by admin. Bookmark the permalink.

Source: http://www.noahswindow.com/interior-design/luxury-house-decorating-ideas-2012

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Sunday, February 26, 2012

Afghan policeman suspect in killing of U.S. officers: sources (Reuters)

[unable to retrieve full-text content]Reuters - Afghan authorities said on Sunday they believe an Afghan police intelligence officer may have been involved in the shooting deaths of two U.S. officers inside the interior ministry a day earlier, prompting NATO to recall all its staff from ministries.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/nm/20120226/wl_nm/us_afghanistan_korans

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Riassunto: Nextreaming annuncia al Mobile World Congress il rilascio di NexEditor per dispositivi Android con processori Snapdragon

Mobile World Congress 2012

Room 3.1HS176

SEUL, Corea--(BUSINESS WIRE)--Nextreaming lancia un'app di qualit? elevata per il video editing dedicata ai dispositivi mobili Android basati su Snapdragon in occasione del Mobile World Congress di Barcellona.

(Le demo si svolgeranno presso la room 3.1HS176 di MWC 2012)

Nextreaming (KOSDAQ:139670), fornitore leader di software multimediale per dispositivi mobili, ha oggi annunciato la disponibilit? di NexEditor, l'editor video totalmente ottimizzato per i processori Snapdragon dual core targati Qualcomm Incorporated. Si tratta di un prodotto ad alte prestazioni con interfaccia utente affidabile al 100% che consente ai dispositivi Android di alta gamma di supportare l'editing foto e video da dispositivi mobili e con un'estrema semplicit? di utilizzo.

NexEditor ? il software di editing eccellente ed affidabile che offre utili funzioni quali ritaglio, split, aggiunta di testo, effetti di transizione, scelta dei temi e la creazione o cancellazione di progetti.

Il testo originale del presente annuncio, redatto nella lingua di partenza, ? la versione ufficiale che fa fede. Le traduzioni sono offerte unicamente per comodit? del lettore e devono rinviare al testo in lingua originale, che ? l'unico giuridicamente valido.

Source: http://feeds.businesswire.com/click.phdo?i=e01fe23c1206f60b3fc4048e41e79a52

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D.A. delayed action on substitute teacher who fled to Mexico

The Los Angeles County district attorney's office chose not to seek the extradition of a substitute teacher wanted for sex crimes, even after prosecutors learned of his whereabouts in Mexico, court records show.

The records contradict statements made this week by a deputy district attorney, who said the teacher would be extradited as soon as authorities could locate him.

The teacher, George Hernandez, was arrested by Huntington Park police in September 2010 for allegedly exposing himself to a girl outside a middle school. Detectives who searched his Inglewood apartment discovered a videotape they say shows Hernandez molesting a second-grader in a classroom. He was released on bail and fled the country.

An investigator working for a bail bonds company found Hernandez early last year, and Jalisco, Mexico, state police briefly detained him on Jan. 19, 2011. In a letter faxed nine days later, the company informed the district attorney that it was continuing to track Hernandez and could help apprehend him.

But on March 15, Deputy Dist. Atty. Ann Huntsman responded saying prosecutors did not want to bring him back to Los Angeles.

"We have evaluated the case and have determined that we will not seek the defendant's international extradition from Mexico on this case at this time," Huntsman wrote. "The case will remain open and the defendant is still subject to prosecution in this case."

The revelation comes in a case that has focused attention on how schools can fail to weed out dangerous teachers. Before his arrest, Hernandez had been investigated three times at three L.A. Unified School District elementary schools for alleged sexual misconduct. He was never charged and apparently never reported to the state commission on teacher credentialing.

Sandi Gibbons, a spokeswoman for the district attorney, said the decision came after consultation with U.S. Justice Department officials, who said success was far from guaranteed.

Prosecutors also considered the fact that Hernandez, now 45, had no criminal record and that the charges they had filed against him ? possession of child pornography and indecent exposure ? fell short of child molestation, Gibbons said.

Huntington Park police, who investigated the case, said they showed prosecutors several videos they found in Hernandez's apartment. Some had been downloaded from the Internet. Others appeared to be homemade, including a 14-minute video in which Hernandez appears alone with a girl detectives said they eventually identified as a 7-year-old student.

Detectives determined that the video was made in 2008 in a classroom at Beulah Payne Elementary, in the Inglewood Unified School District, while Hernandez was filling in for a teacher on leave. According to their investigative report, he repeatedly reached under the girl's clothes and placed her across his lap, as she tried to resist.

Gibbons said prosecutors determined the strongest charge the evidence could support was felony possession of child pornography. The charge was based only on a video taken from the Internet, she said. Prosecutors were never shown the evidence related to the video of the child in the classroom, Gibbons said.

"We presented what we had and they didn't feel that was enough for more serious charges," Huntington Park Lt. Anthony Porter said Friday.

Inglewood schools hired Hernandez in 2007 after he had left L.A. Unified under a cloud of suspicion. His 2010 arrest ? and his flight soon after ? received little public attention at the time. But if Hernandez remained a fugitive, Aladdin Bail Bonds stood to lose his $30,000 bail.

The company hired a Mexican investigator, Antonio Oswaldo Ramirez Perez; and in January 2011, he went to San Miguel el Alto, where Hernandez had spent his early childhood before moving to the United States. It wasn't hard to find him.

"It's a very small town," Ramirez said by phone this week. "He was well known."

Hernandez drove a red Ford pickup with Jalisco license plates. He was living in the center of town in a small house that Ramirez thought belonged to Hernandez's relatives and he didn't have a job.

With help from the Jalisco state police, Ramirez photographed Hernandez holding a Mexican newspaper, collected his fingerprints and copied down his driver's license number.

The information was included in the bail company's Jan. 28, 2011, letter to the L.A. County district attorney. "Aladdin's investigators remain aware of the defendant's whereabouts and can assist in the apprehension of the defendant if Los Angeles County law enforcement authorities wish to commence extradition efforts of the defendant in this case," it said.

It was filed in court, along with the response from the district attorney.

Under California law, a bail company can keep its money if it locates a fugitive abroad and provides the information to prosecutors. On April 5, a judge ruled that Aladdin was off the hook.

After The Times published an article about Hernandez's case this week, L.A. County Deputy Dist. Atty. Diana Martinez said he would be extradited as soon as his exact location could be determined.

There has been no such effort "because that requires we know where he is," she said in an interview Wednesday.

Gibbons said Martinez was not aware Hernandez had been located or of the discussions about his possible extradition. The case remains open, she added.

Meanwhile, Hernandez's family has been begging him to return, according to a relative, who said, "All of his actions have shown what a coward he is, and I doubt he will come back."

alan.zarembo@latimes.com

richard.winton@latimes.com

Source: http://feeds.latimes.com/~r/latimes/news/local/crime/~3/bE6qiFuJSyg/la-me-0225-substitute-teacher-20120225,0,2954864.story

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Saturday, February 25, 2012

Where to Get Your Ezine Content

Coming up with your own content is always a challenge when publishing your own online eZine.


No matter what topic you?ve chosen to publish on your eZine, types of contents can more or less be classified into four groups namely factual content, case studies, short tips or how-tos and mini stories.


Besides writing your own content, you can also get unique content by interviewing an expert in the topic of your choice. No more cases of writer?s block for you because here, the interviewee will do all the work. And because essentially, these interviews are free, you need to give the interviewee something valuable in return ? say free dinner or maybe tickets to a concert.


If you can afford to hire a ghost writer and take credit for the work, you may do so. There are many places online where you will find reliable freelance writers to write your content for you.

You can search using your favorite search engine for this.


Another way for you to get good content is through public domains. Public domain only means that the articles/blogs your are reading are NOT protected under US copyright law. As long as nobody claims to own them, it is safe for you to use. This is a great way to get good quality content without having to spend a dime for it.


These public domains include all works published before 1923, and some that are publish up until 1978. Works pertain to written materials such as reports, articles and books.


Using public domain information by republishing and rewriting/repackaging them is a great way for you to get quality articles. It can save time and effort because you don?t have to write them yourself. You need not stress yourself out thinking of what kind of content you need to publish next. The greatest thing about it is that you don?t have to pay royalties and copyright fees for them.


If publishing great articles without having to spend anything appeals to you, then I advise you try this method.

Source: http://www.1directory.net/internet-and-businesses-online/where-to-get-your-ezine-content-7969.html

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The Undoing of Posting Houses

Individuals who?ve read these articles on e-books and radio on the web knows I?m a fan from the new media.

Today a literary agent explained an impressive factor: he?d sent twelve, most probably perfectly good, works of fiction to numerous established posting houses which switched them lower, unread, unconsidered, simply because they have been formerly self-released. Two reasons received with this, the first is self-obviously false and also the other is absurd. The very first reason would be that the writer could be competing using the author, I am unable to even call that the lie, as everybody involved knows the writer requires a unique contract of all the author. Second is that everybody who might ever buy the book has done this! It is primarily the second reason which prompts me to create it not just indicates the ridiculous proposition that anybody who didn?t purchase a book on some arbitrary and most likely unknown publication date won?t ever later on are interested that book, additionally, it comprises a line which may get anybody, in almost any other place of sales or marketing, instantly ignored. It is said that it?s just the immediate time following a book continues to be released they, themselves, make any effort to market it I seriously hope which is false. If it is true, lots of authors have cause of the gravest worry about their marketers, and really should review if they?d like to get free from their exclusive posting contracts and self-publish rather.

If your book continues to be released whatsoever it?s been raised with a kind of standard, even when this really is not so high, it must be better and require less work than the usual raw manuscript. Towards the exact contrary of the items the literary agent explained, marketers should welcome the formerly self-released the writer presently has some sense of the down sides of publication and also the writer can easily see what labored and what didn?t in getting it towards the market.

Actually, exactly what the marketers who rejected that literary agent might more plausibly have meant is that they don?t have any confidence that they?ll inflict better job, for those their many years of experience, than the usual completely unskilled amateur.

Such marketers can also be happening what is an incorrect assumption somebody that has already been released would only visit them when the publication was not successful. That assumption also sucks me of confidence in marketers.

When I take a look at posting within the British language, within the a lot more than five centuries since Caxton, it seems in my experience that marketers have no clue what sells books, or steps to make books appealing to purchasers. It seems they depend around the fame of the author?s title, as well as on the assumption that the author that has written a very common book can write another. The best illustration of the fallacy of this assumption is Jerome K. Jerome, although the perfect example might be Laurence Sterne, who getting written perhaps the very best novel within the British language, also authored ?A sentimental Journey?.

Basically possessed shares inside a writer, or maybe I had been used in posting, I?d allow it to be my first priority to discover why individuals are attracted towards the books they choose, and what they wish to see inside them. Does the posting industry make any effort to discover? Or perhaps is complacency total within the dereliction of the duty privately, their authors and also the public? When they apply no consideration apart from previous publication to rejecting manuscripts I?m afraid it?s the latter.

But marketers should beware. If there?s any truth within their tacit admission that the completely lack of experience amateur can perform in addition to them, they?ll shortly discover that authors simply eliminate posting houses in the end, if they don?t know their very own business, what good could they be?

Ink jet printers, publicists, book marketers and merchants, editors and proof visitors all work individually, even when you will find some in-house editors and proof visitors. Given a thing-processor and a web connection, authors really don?t have any necessity of posting houses as well as the necessity of these experts mainly concerns traditional posting. You will find now literally 100s of 1000?s of e-books released every year. A writer can perform their own formatting, editing, proofing and art-focus on a pc, the effect can result in promoted direct through Amazon . com or Barnes & Noble all a writer really needs from the outdoors agency is definitely an ISBN number.

You will find wealthy and famous authors maybe they think marketers have offered them well. To individuals effective people I?d request what amount of the make money from your book involves you. Maybe it was the writer who made you famous? In case your fame rests exclusively in your writing, isn?t it the general public you need to credit? Why don?t you lessen the cost of the books and the publisher?s share yourself?

Revisit the literary agent with whom we began, and also to all literary agents you shouldn?t be blamed for that failure of posting houses, your work ought to be safe. Obviously, your work may later on be representing authors to testers and also the public, to not marketers. I really hope most of the better literary agents will discover mtss is a relief. I shall send a duplicate want to know , towards the agent under consideration.

Source: http://arts-short-fiction.chailit.com/the-undoing-of-posting-houses.html

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The BRAD BLOG : Previously Legal WI Voters Turned Away at Polls ...

READER COMMENTS ON
"Previously Legal WI Voters Turned Away at Polls Tuesday as GOP's New Photo ID Restrictions Begin"
(14 Responses so far...)

COMMENT #1 [Permalink]
... hardline said on 2/23/2012 @ 3:41 pm PT...

If you're not smart enough to get a valid I.D. and carry it to the polls then you have no business voting. The issues typically voted on are far more complex than the process of obtaining a picture I.D. Those that advocate for easy, non-verifiable voter registration desire ignorant voters, and rampant fraud, enabling big money to infleuence outcomes rather than allowing well thought out ideas to florish.


COMMENT #2 [Permalink]
... Madison VOICES said on 2/23/2012 @ 5:00 pm PT...

hardhead (or whatever) above is being disengenuous at best - no surprise that he wants to make this about some type of voter "test". The party he probably supports in Wisconsin literally stole money from the widows and orphans of solders who gave their lives serving our nation.

Walker's aides, with walker's help, stole money from a support group to pay for walker's website and take vacations in exotic place with their homosexual live-in boyfriend. Even worse, the 2 had gay child porn on their computers!

For the latest in fitzwalkerstan antics, please visit our Web or new blog and tv channel.

You may have seen this, the husband of walker's lieutenant governor whom I have personally seen drunk and staggering into the assembly chamber to vote (illegal in Wisconsin) is committing vote fraud himself!

Must see video

Too bad the above commentator won't apply the same standards to the other side - he thinks voters need to pass a phony IQ test by jumping through hoops to participate in our democracy and most-likely supports repugs voting while drunk on major bills (in this case, it was the mining bill!)

Keep up the good work on election fraud.


COMMENT #3 [Permalink]
... Mike Leon said on 2/23/2012 @ 5:19 pm PT...

Now, a federal complaint need not make a facial challenge to Wisconsin's voter obstruction (voter impersonation as you point out) law. See Brennan Center: "future (federal) challenges to voter laws must be filed with respect to the application of a specific law?after its controversial mandates are already applied in an election,"
-http://www.brennancenter.org/content/resource/brennan_center_criticizes_supreme_court_decision_to_uphold_indiana_voter_id/

This law is so blatantly unonstitutional that I think even the corrupt 4-3 majority on the Wisconsin Supreme Court will have to enjoin the law as voting in Wisconsin is extremely well-protected under Wisconsin Constitutional law, upholding law would cause them to look even more foolish than they do now.

So, in both state and federal court, we are looking good.

As for Hardline's comment, I suggest you read up on the difference between voter registration and poll ID requirements. If I may suggest:
http://malcontends.blogs...-reality-overlooked.html


COMMENT #4 [Permalink]
... tmm said on 2/23/2012 @ 5:25 pm PT...

LOL @ hardline's comments.

"Rampant fraud"!

Where? In the deluded fantasyland where ACORN got Obama elected?

And those "complex issues"! Hilarious - you do realize it's a pres primary? "Which of these clowns do I hate least" is not complex to most of us.

How does the "big money" bit have anything to do w/ turning away legal voters who've voted for decades? Weere you looking for a Citizens United thread?


COMMENT #5 [Permalink]
... Big Dan said on 2/23/2012 @ 6:00 pm PT...

IRONY ALERT:

Comment #1 says only smart people should vote. I guess that leaves him out, because he misspelled "influence" and "flourish", and furthermore probably has spell checker.


COMMENT #6 [Permalink]
... Ernest A. Canning said on 2/23/2012 @ 6:08 pm PT...

hardline @1 wrote:

If you're not smart enough to get a valid I.D. and carry it to the polls then you have no business voting

Fact: Intelligence has nothing to do with it.

In its federal lawsuit challenging the WI photo ID law, the ACLU identified six categories of WI residents who lack the requisite form of photo ID mandated by the statute and who face severe, and at times, impossible burdens.

This included 84-year old Ruthelle Frank, who voted in every election since 1948 and was a member of the Brokaw Village Board but cannot get the GOP approved official state photo ID.

She was born at home, without a birth certificate, and will be forced to pay $20 to get one in order to get her supposedly "free" ID to vote. But even that may not be enough. Frank recently learned she may not be able to comply with the state GOP's Photo ID restriction unless she coughs up upwards of $200 to amend the Register of Deeds record of her home, which had misspelled her maiden name.

Hardline writes:

Those that advocate for easy, non-verifiable voter registration desire...rampant voter fraud.

Fact: There is only one form of "voter fraud" that can be prevented by polling place photo ID laws --- in person impersonation. That form of "voter fraud" is virtually non-existent.

As Loyola Law Prof. Justice Levitt noted in written testimony before the U.S. Senate, since 2000, there were "nine allegations of votes [in general elections] that might have involved votes cast by individuals impersonating others," but those nine may be the result of "poll worker error or voter confusion...During the same period, 400 million votes were cast...Even assuming that each of the nine votes were fraudulent, that amounts to a relevant fraud rate of 0.000002 percent. Americans are struck and killed by lightning more often."

Polling place photo ID has been pushed by Republicans, like convicted felon Charlie White, for one reason only. Photo ID will have a disparate impact on the right for minorities, the poor and the elderly to vote --- that is on those who are not likely to vote for the Party of the One Percent aka the GOP.


COMMENT #7 [Permalink]
... Soul Rebel said on 2/23/2012 @ 8:57 pm PT...

The Voter ID laws are a new tax!

Hopefully the people like the Veteran pictured will - if they were (R) - realize that the (R) serve nobody but the ultra-rich and their corporate masters. The (R) could do themselves in over this...everybody'll know somebody who gets caught up in this.


COMMENT #8 [Permalink]
... novenator said on 2/24/2012 @ 3:56 am PT...

Conservative politicians hate democracy, and are doing everything in their power to suppress it.


COMMENT #9 [Permalink]
... Dredd said on 2/24/2012 @ 4:14 am PT...

Indiana is no newcomer to sneaky snake laws.

Indiana Congressional District 9 snaked through parts of 20 counties before the 2010 census.

Can you imagine contesting a House election where you had to contest it in portions of 20 counties, or deal with the precincts in portions of 20 counties (I need the voting records of only parts of 20 county election clerks)?

And that is not the worst part of the debacle.

My guess is that Indiana politicians will try to make their gerrymandering worse, not better.


COMMENT #10 [Permalink]
... WDRussell said on 2/24/2012 @ 5:50 am PT...

These states are telling people that they have to prove themself innocent of voter fraud.
That goes against the most basic section of our judicial system.
A person is NEVER required to prove themself innocent.


COMMENT #11 [Permalink]
... donn witherspoon said on 2/24/2012 @ 7:45 am PT...

I have been in VA hospitals on and off for over 30 years. I have met multiple veterans who cannot drive due to wounds received in service. To deny a veteran with a government issued valid ID just shows that the Republicans know they cannot win a a fair election. So they do all they can to remove the folks that would vote against them. It is a shame any veteran is treated this way. I wonder how many Republican legislators that voted for this are veterans.


COMMENT #12 [Permalink]
... Seb Stenjem said on 2/24/2012 @ 8:26 am PT...

Another thing that should be remembered. The DMV, where one can get an ID, was not required to tell you that your ID would be free. Instead, if you failed to check the box, they then charged you for it. And they also closed DMV offices or at least reduced the hours of operation.
They have allowed a few more ID forms, but it's still a very select few. This suprising they let this group slip. MANY of them support the spoiled little Rich boys. Maybe they think corporate $ and redistricting will be enough?


COMMENT #13 [Permalink]
... Dredd said on 2/24/2012 @ 8:40 am PT...

Wisconsin's District 3 goes through all or part of 20 counties.

WI is no piker at gerrymandering or vote suppression.


COMMENT #14 [Permalink]
... JerryW said on 2/24/2012 @ 10:13 am PT...

This vet chose to make an issue of the VA card. He had a valid drivers license and wouldn't use it. It was his way of getting 15 minutes of fame.


Source: http://www.bradblog.com/?p=9139

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Harry Turtledove Makes Terminal Cancer Patient&#39;s Dream Come ...

By Jason Boog on February 23, 2012 5:06 PM

While his friend Nachu Bhatnagar battled terminal cancer, Reddit user Kivakid turned to the online community to help make his friend?s wish come true: to find out how Harry Turtledove?s book series The War That Came Early will end.

Through the magic of Reddit, an editor in the Reddit community gave this reader a gift he will never forget. You can watch? Bhatnagar receive his gift in the video embedded above?the moving video contains a bit of NSFW language.

Here?s more from Social Times: ?While the concluding books in the series won?t be out for a few years, the publisher sent an advanced copy of the latest book in the series and Harry Turtledove even agreed to speak on the phone with Nachu about the rest of the series. This amazingly heartwarming story wouldn?t have been possible without Reddit.?

Source: http://www.mediabistro.com/galleycat/harry-turtledove-makes-terminal-cancer-patients-dream-come-true_b47490

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Friday, February 24, 2012

Imagining A More Active Moon

Copyright ? 2012 National Public Radio?. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.

IRA FLATOW, HOST:

This is SCIENCE FRIDAY. I'm Ira Flatow. When you think about the moon, once you get pass thinking about Apollo, the moonlit romance, maybe cheese, your next thought is: so what? It's a big rock, a gray, dead place. But new research hints that the moon may not be as dead geologically as we might think. That on the far side of the moon there are signs of tectonic activity, recent, within the last 50 million years - counts as recent in geological time. Joining me now to tell us all about it is Tom Watters, one of the authors of that report published this week in the journal Nature Geoscience.

He's a senior scientist at the Center for Earth and Planetary Studies at the Smithsonian National Air and Space Museum in Washington. Welcome back to the program, Tom.

DR. THOMAS R. WATTERS: Hi, Ira. It's a pleasure to be back.

FLATOW: You're very welcome. Tell us what are these - what's the evidence of recent 50-million-year-old tectonic activity on the far side?

WATTERS: Well, it's an interesting story, and it starts, not quite two years ago when I was on before, and talked about the shrinking moon that we had located using very high-resolution images obtained from the Lunar Reconnaissance Orbiter, which has been in orbit around the moon since 2009. We saw these features, these land forms that indicate that the lunar crust was actually shrinking. It was being contracted and forming these fault scarps. So we went looking for more of these.

Now that we are continuing to get more and more coverage of the moon with these very high-resolution images, and we found something we weren't expecting. We found just the opposite of the type of land forms that indicate contraction. We found land forms that indicate that the moon is actually expanding and being stretched and pulling apart - not by much, but a little bit. And these features actually are very narrow, very relatively long troughs that are formed when the crust of the moon is being pulled apart and just breaks and then a section of it drops down.

FLATOW: Wow. Wow. And what would be pulling it apart?

WATTERS: Well, that's an excellent question, and it's one of the really interesting aspects of the research that we need to continue to do because we're not exactly sure what is causing this stretching within these small areas because, again, here we've had this picture of a now contracting moon. We have evidence for these global contractional faults, and here now we have evidence of...

FLATOW: Stretch marks.

WATTERS: Yes. Exactly.

(SOUNDBITE OF LAUGHTER)

FLATOW: Stretch marks. You didn't want to say it, so I said it for you.

WATTERS: Yeah. It's funny. You know, you wrack your brain thinking about creative ways of describing, you know, technical jargon, and...

(SOUNDBITE OF LAUGHTER)

WATTERS: ...stretch marks never occurred to me. But it's actually a very appropriate, very accurate way of describing these things. So, yeah, we're trying to figure out what are the forces that are acting to pull the moon apart in places that are competing with these forces that are acting to shrink the moon. And there's a couple of possibilities. One intriguing one is the possibility that these areas that are being - are actually being picked up and kind of stretched because magma is trying to rise below the surface.

It doesn't make it to the surface, but it's trying to rise below - to rise up and, again, as it does, it sort of lifts it up and cracks it and stretches it. The trouble with that model is, though, that we don't see any evidence for really, really young volcanic material on the surface of the moon.

FLATOW: Yeah.

WATTERS: But the - yeah. It's really interesting how young these features appear to be.

FLATOW: So you - do you think that there some day might be a volcano that we might discover or one that will actually spouts out, and it's easy to see from your orbiting stuff?

WATTERS: I would not say no, but I also wouldn't make any bets...

(SOUNDBITE OF LAUGHTER)

WATTERS: ...that that's likely to happen.

FLATOW: That's called hedging your bets.

(SOUNDBITE OF LAUGHTER)

WATTERS: Right.

FLATOW: But it should be. But if you're saying - what you're saying, if I hear you correctly - now I'll put words in your mouth - is that if there is molten lava under the moon, it should spout out someplace.

WATTERS: Well, it's possible.

FLATOW: It's possible.

WATTERS: It all depends on the conditions. I mean, there are, again, other possibilities for how these stretch marks, as you described them...

FLATOW: Yeah.

WATTERS: ...may have formed on the moon. And another possibility is that they are connected with the fact that the moon is actually contracting. And what happens - at least theoretically - as the moon is contracting, blocks of the crust may actually be bent and flexed as part of that contractional process. But we still have a lot of work to understand this. Again, some of my colleagues are not particularly thrilled with the idea of young volcanism on the moon. But, again, one of the things that's really fascinating about these features are their youth. I mean, we have looked at these contractional faults scarps, and we knew that they were younger than a billion years, and we knew that they were likely much younger than a billion years. Maybe hundreds of millions of years old, maybe even tens of millions of years old, but we couldn't be sure.

One thing that's really interesting about these very, very small, narrow graven features as we call them is that they won't survive long at all on the moon because they're just very shallow. And the moon is an active place in terms of micrometeorite bombardments, and soil gets picked up and deposited, and so very small, very shallow-depth trenches will actually be filled in. And we know this from looking at boulder tracts of all things, boulders that have rolled down.

There's a greater paper that was done in the mid '70s where an analysis of boulders that have rolled off a hill near the Apollo 17 site created a track. One of them had a track, another one didn't have a track. And by dating the age of the boulders, the - we can actually date how long that boulder had been sitting there. We knew when it rolled down the hill we could determine how quickly these trenches would fill in. So that's really exciting because it gave us another way to date these that we couldn't use to date these contractional fault scarps.

So we know these trenches can't be anymore than 50 million years old, but that is so recent in geologic terms, Ira, that these things could be not only just 50 million years old, they could be 10, they could one million years old. They could have been active 40 years ago, and that's the other intriguing possibility, is you have...

FLATOW: And you have there your science fiction music coming up.

(SOUNDBITE OF LAUGHTER)

WATTERS: Well, we had the great Apollo seismic network that was on the moon put up by the Apollo astronauts and operated for a number of years collecting data on seismic activity in the moon, and the moon was active seismically very deep. But there is also a small number of moonquakes that occurred within the crust of the moon, and it's not impossible that those moonquakes are connected to these very, very young tectonic features.

FLATOW: So they could be really young...

WATTERS: Yes.

FLATOW: ...I mean, 40 years ago.

WATTERS: Yes.

FLATOW: Wow. And men were on the moon when they were happening.

(SOUNDBITE OF LAUGHTER)

WATTERS: And could be.

FLATOW: Does the moon have plates like tectonic plates like we have on the moon?

WATTERS: No. The moon is in the - well, let's put it this way. The Earth is really unique among the terrestrial planets in that it has this mosaic of plates that shift and collide into one another or shift past one another. And again, most of the tectonic activity and volcanic activity on the Earth is concentrated at these plate boundaries. The moon is like a one-plate object. The moon, Mercury, other planets in the solar system appear to be one-plate objects. So when they contract globally, it's acting on a single plate.

FLATOW: Yeah. So the other question being, if the astronauts were on the moon, why did they not see any of these stretch marks on their side of their moon? And you haven't found it on the bright side, so to speak, that's facing us.

WATTERS: Well, there actually are some on the near side, but you're right. Some of the most exciting - actually the most exciting example that found is on the far side. It's almost exactly on the opposite side of the moon that faces the Earth. And it may, again, be that there are just subtle forces that are acting within the moon that are creating just enough force to create these graven. It's also interesting because it tells us something about the stress state of the moon very recently, and that helps us figure out how the moon evolved and maybe even how the moon formed.

FLATOW: But you're not giving up - that doesn't bash the idea that the Earth was hit by another body and smashed the moon off as a piece?

WATTERS: No. No.

FLATOW: That's still the active - that doesn't do anything to that theory.

WATTERS: No. This actually picks up when all that is over, and the moon has actually coalesced and formed. And it's the sort of the history of the moon from that point on, that these kind of observations could very helpful in determining, again, the moon's evolution.

FLATOW: You know what you're doing. You're making the moon more interesting, which is dangerous, I think.

(SOUNDBITE OF LAUGHTER)

FLATOW: It's that people want to go back and study this stuff that we never thought we'd have to wonder about it, right, you know?

WATTERS: Well, that's true. I mean, I - one thing I want to mention is just - and it's very exciting - again, this is one of the exciting things about being planetary scientist. Right now, we have imaged less than half of the moon with this very, very high-resolution images coming back from The Lunar Reconnaissance Orbiter. So we have, again, literally, more than half the moon to image with these, again, very high-resolution images, and we're very excited about the idea of finding more tectonic features, more features - more surprises. And that's really one of the exciting things about exploration.

FLATOW: Yeah, it is. And how long will it take to finish the job here with those photos?

WATTERS: To do the job completely, we may need about four more years, an extended mission. It takes quite awhile. So we've been in orbit since 2009, and here we are, 2012, and we're still collecting data. So quite awhile, and we're hoping to have an extended mission that will allow us to do that.

FLATOW: You mean like the little Mars rovers keep - just keep going with your mission.

WATTERS: Yes. Well, we're very fortunate. The Lunar Reconnaissance Orbiter spacecraft is extremely healthy. We're in a very stable orbit. We could easily operate for four more years.

FLATOW: Do you have the budget for that?

WATTERS: Well, that's the question. I can't answer that.

(SOUNDBITE OF LAUGHTER)

FLATOW: As they say in Washington, that's above your pay grade, correct?

WATTERS: Exactly. You took the words right out of my mouth.

(SOUNDBITE OF LAUGHTER)

FLATOW: Well, you can always hope, you know. Look what - you can point to the success and the Mars rovers and things just keep going and finish the rest of the moon.

WATTERS: Well, you think about it, too, it's a great investment. We've got - it's a relatively small amount of money compared to what it would cost to rebuild a spacecraft like the Lunar Reconnaissance Orbiter and put it in lunar orbit.

FLATOW: Well, you know what's on your side is exploring the moon has already been thrown into the presidential race, in a different context, but we might have some other ideas here.

WATTERS: Yes, it's possible. One of the interesting connections was the idea of whether a moon base would actually survive now based on these new findings. And I think I can safely tell you that the moon base would not be in great jeopardy unless you actually built it on a fault surface.

FLATOW: All right. Tom, that's quite fascinating. Thank you very much for taking time to be with us today.

WATTERS: My pleasure.

FLATOW: Tom Watters, senior scientists at the Center for Earth and Planetary Studies at the Smithsonian National Air and Space Museum in Washington. This is SCIENCE FRIDAY from NPR.

Copyright ? 2012 National Public Radio?. All rights reserved. No quotes from the materials contained herein may be used in any media without attribution to National Public Radio. This transcript is provided for personal, noncommercial use only, pursuant to our Terms of Use. Any other use requires NPR's prior permission. Visit our permissions page for further information.

NPR transcripts are created on a rush deadline by a contractor for NPR, and accuracy and availability may vary. This text may not be in its final form and may be updated or revised in the future. Please be aware that the authoritative record of NPR's programming is the audio.

Source: http://www.npr.org/2012/02/24/147356634/imagining-a-more-active-moon?ft=1&f=1007

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How cells brace themselves for starvation

ScienceDaily (Feb. 23, 2012) ? Sugar, cholesterol, phosphates, zinc -- a healthy body is amazingly good at keeping such vital nutrients at appropriate levels within its cells. From an engineering point of view, one all-purpose model of pump on the surface of a cell should suffice to keep these levels constant: When the concentration of a nutrient, say, sugar, drops inside the cell, the pump mechanism could simply go into higher gear until the sugar levels are back to normal. Yet strangely enough, such cells let in their nutrients using two types of pump: One is active in "good times," when a particular nutrient is abundant the cell's environment; the other is a "bad-times" pump that springs into action only when the nutrient becomes scarce. Why does the cell need this dual mechanism?

A new Weizmann Institute study, reported in Science, might provide the answer. The research was conducted in the lab of Prof. Naama Barkai of the Molecular Genetics Department by postdoctoral fellow Dr. Sagi Levy and graduate student Moshe Kafri with lab technician Miri Carmi.

It had been known for a while that when the levels of phosphate or zinc drop in the surroundings of a yeast cell, the number of "bad-times" pumps on the cell surface soars up to a hundred-fold. When phosphate or zinc becomes abundant again, the "bad-times" pumps withdraw while the "good-times" pumps return to the cell surface in large numbers. In their new study, the scientists discovered that cells which repress their "bad-time" pumps when a nutrient is abundant were much more efficient at preparing for starvation and at recovering afterwards than the cells that had been genetically engineered to avoid this repression. The conclusion: The "good-times" pumps apparently serve as a signaling mechanism that warns the yeast cell of approaching starvation. Such advance warning gives the cell more time to store up on the scarce nutrient; the thorough preparation also helps the cell to start growing faster once starvation is over.

Thus, the dual-pump system appears to be part of a regulatory mechanism that allows the cell to deal effectively with fluctuations in nutrient supply. This clever mechanism offers the cell survival advantages that could not be provided by just one type of pump.

If these findings prove to be applicable to human cells, they could explain how our bodies maintain adequate levels of various nutrients in tissues and organs. Understanding the dual-pump regulation could be crucial because it might be defective in various metabolic disorders.

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Story Source:

The above story is reprinted from materials provided by Weizmann Institute of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. Levy, M. Kafri, M. Carmi, N. Barkai. The Competitive Advantage of a Dual-Transporter System. Science, 2011; 334 (6061): 1408 DOI: 10.1126/science.1207154

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/02/120223103914.htm

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Baby shower etiquette question re location

[unable to retrieve full-text content]Why is having a shower at home weird? Most of the family showers I go to are at a home and very well done. My sister had her 100 person baby shower at home with plenty of space, decorations, catered food, games etc, and ...

Source: http://www.dcurbanmom.com/jforum/posts/preList/211771/2187125.page

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Thursday, February 23, 2012

Blood mystery solved

Blood mystery solved [ Back to EurekAlert! ] Public release date: 23-Feb-2012
[ | E-mail | Share Share ]

Contact: Joshua Brown
joshua.e.brown@uvm.edu
802-656-3039
University of Vermont

2 new blood types decoded

You probably know your blood type: A, B, AB or O. You may even know if you're Rhesus positive or negative. But how about the Langereis blood type? Or the Junior blood type? Positive or negative? Most people have never even heard of these.

Yet this knowledge could be "a matter of life and death," says University of Vermont biologist Bryan Ballif.

While blood transfusion problems due to Langereis and Junior blood types are rare worldwide, several ethnic populations are at risk, Ballif notes. "More than 50,000 Japanese are thought to be Junior negative and may encounter blood transfusion problems or mother-fetus incompatibility," he writes.

But the molecular basis of these two blood types has remained a mystery until now.

In the February issue of Nature Genetics, Ballif and his colleagues report on their discovery of two proteins on red blood cells responsible for these lesser-known blood types.

Ballif identified the two molecules as specialized transport proteins named ABCB6 and ABCG2.

"Only 30 proteins have previously been identified as responsible for a basic blood type," Ballif notes, "but the count now reaches 32."

The last new blood group proteins to be discovered were nearly a decade ago, Ballif says, "so it's pretty remarkable to have two identified this year."

Both of the newly identified proteins are also associated with anticancer drug resistance, so the findings may also have implications for improved treatment of breast and other cancers.

As part of the international effort, Ballif, assistant professor in UVM's biology department, used a mass spectrometer funded by the Vermont Genetics Network. With this machine, he analyzed proteins purified by his longtime collaborator, Lionel Arnaud at the French National Institute for Blood Transfusion in Paris, France.

Ballif and Arnaud, in turn, relied on antibodies to Langereis and Junior blood antigens developed by Yoshihiko Tani at the Japanese Red Cross Osaka Blood Center and Toru Miyasaki at the Japanese Red Cross Hokkaido Blood Center.

After the protein identification in Vermont, the work returned to France. There Arnaud and his team conducted cellular and genetic tests confirming that these proteins were responsible for the Langereis and Junior blood types. "He was able to test the gene sequence," Ballif says, "and, sure enough, we found mutations in this particular gene for all the people in our sample who have these problems."

Beyond the ABO blood type and the Rhesus (Rh) blood type, the International Blood Transfusion Society recognizes twenty-eight additional blood types with names like Duffy, Kidd, Diego and Lutheran. But Langereis and Junior have not been on this list. Although the antigens for the Junior and Langereis (or Lan) blood types were identified decades ago in pregnant women having difficulties carrying babies with incompatible blood types, the genetic basis of these antigens has been unknown until now.

Therefore, "very few people learn if they are Langereis or Junior positive or negative," Ballif says.

"Transfusion support of individuals with an anti-Lan antibody is highly challenging," the research team wrote in Nature Genetics, "partly because of the scarcity of compatible blood donors but mainly because of the lack of reliable reagents for blood screening." And Junior-negative blood donors are extremely rare too. That may soon change.

With the findings from this new research, health care professionals will now be able to more rapidly and confidently screen for these novel blood group proteins, Ballif wrote in a recent news article. "This will leave them better prepared to have blood ready when blood transfusions or other tissue donations are required," he notes.

"Now that we know these proteins, it will become a routine test," he says.

This science may be especially important to organ transplant patients. "As we get better and better at transplants, we do everything we can to make a good match," Ballif says. But sometimes a tissue or organ transplant, that looked like a good match, doesn't work and the donated tissue is rejected, which can lead to many problems or death.

"We don't always know why there is rejection," Ballif says, "but it may have to do with these proteins."

The rejection of donated tissue or blood is caused by the way the immune system distinguishes self from not-self. "If our own blood cells don't have these proteins, they're not familiar to our immune system," Ballif says, so the new blood doesn't "look like self" to the complex cellular defenses of the immune system. "They'll develop antibodies against it," Ballif says, and try to kill off the perceived invaders. In short, the body starts to attack itself.

"Then you may be out of luck," says Ballif, who notes that in addition to certain Japanese populations, European Gypsies are also at higher risk for not carrying the Langereis and Junior blood type proteins.

"There are people in the United States who have these challenges too," he says, "but it's more rare."

Ballif and his international colleagues are not done with their search. "We're following up on more unknown blood types," he says. "There are probably on the order of 10 to 15 more of these unknown blood type systems where we know there is a problem but we don't know what the protein is that is causing the problem."

Although these other blood systems are very rare, "if you're that one individual, and you need a transfusion," Ballif says, "there's nothing more important for you to know."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Blood mystery solved [ Back to EurekAlert! ] Public release date: 23-Feb-2012
[ | E-mail | Share Share ]

Contact: Joshua Brown
joshua.e.brown@uvm.edu
802-656-3039
University of Vermont

2 new blood types decoded

You probably know your blood type: A, B, AB or O. You may even know if you're Rhesus positive or negative. But how about the Langereis blood type? Or the Junior blood type? Positive or negative? Most people have never even heard of these.

Yet this knowledge could be "a matter of life and death," says University of Vermont biologist Bryan Ballif.

While blood transfusion problems due to Langereis and Junior blood types are rare worldwide, several ethnic populations are at risk, Ballif notes. "More than 50,000 Japanese are thought to be Junior negative and may encounter blood transfusion problems or mother-fetus incompatibility," he writes.

But the molecular basis of these two blood types has remained a mystery until now.

In the February issue of Nature Genetics, Ballif and his colleagues report on their discovery of two proteins on red blood cells responsible for these lesser-known blood types.

Ballif identified the two molecules as specialized transport proteins named ABCB6 and ABCG2.

"Only 30 proteins have previously been identified as responsible for a basic blood type," Ballif notes, "but the count now reaches 32."

The last new blood group proteins to be discovered were nearly a decade ago, Ballif says, "so it's pretty remarkable to have two identified this year."

Both of the newly identified proteins are also associated with anticancer drug resistance, so the findings may also have implications for improved treatment of breast and other cancers.

As part of the international effort, Ballif, assistant professor in UVM's biology department, used a mass spectrometer funded by the Vermont Genetics Network. With this machine, he analyzed proteins purified by his longtime collaborator, Lionel Arnaud at the French National Institute for Blood Transfusion in Paris, France.

Ballif and Arnaud, in turn, relied on antibodies to Langereis and Junior blood antigens developed by Yoshihiko Tani at the Japanese Red Cross Osaka Blood Center and Toru Miyasaki at the Japanese Red Cross Hokkaido Blood Center.

After the protein identification in Vermont, the work returned to France. There Arnaud and his team conducted cellular and genetic tests confirming that these proteins were responsible for the Langereis and Junior blood types. "He was able to test the gene sequence," Ballif says, "and, sure enough, we found mutations in this particular gene for all the people in our sample who have these problems."

Beyond the ABO blood type and the Rhesus (Rh) blood type, the International Blood Transfusion Society recognizes twenty-eight additional blood types with names like Duffy, Kidd, Diego and Lutheran. But Langereis and Junior have not been on this list. Although the antigens for the Junior and Langereis (or Lan) blood types were identified decades ago in pregnant women having difficulties carrying babies with incompatible blood types, the genetic basis of these antigens has been unknown until now.

Therefore, "very few people learn if they are Langereis or Junior positive or negative," Ballif says.

"Transfusion support of individuals with an anti-Lan antibody is highly challenging," the research team wrote in Nature Genetics, "partly because of the scarcity of compatible blood donors but mainly because of the lack of reliable reagents for blood screening." And Junior-negative blood donors are extremely rare too. That may soon change.

With the findings from this new research, health care professionals will now be able to more rapidly and confidently screen for these novel blood group proteins, Ballif wrote in a recent news article. "This will leave them better prepared to have blood ready when blood transfusions or other tissue donations are required," he notes.

"Now that we know these proteins, it will become a routine test," he says.

This science may be especially important to organ transplant patients. "As we get better and better at transplants, we do everything we can to make a good match," Ballif says. But sometimes a tissue or organ transplant, that looked like a good match, doesn't work and the donated tissue is rejected, which can lead to many problems or death.

"We don't always know why there is rejection," Ballif says, "but it may have to do with these proteins."

The rejection of donated tissue or blood is caused by the way the immune system distinguishes self from not-self. "If our own blood cells don't have these proteins, they're not familiar to our immune system," Ballif says, so the new blood doesn't "look like self" to the complex cellular defenses of the immune system. "They'll develop antibodies against it," Ballif says, and try to kill off the perceived invaders. In short, the body starts to attack itself.

"Then you may be out of luck," says Ballif, who notes that in addition to certain Japanese populations, European Gypsies are also at higher risk for not carrying the Langereis and Junior blood type proteins.

"There are people in the United States who have these challenges too," he says, "but it's more rare."

Ballif and his international colleagues are not done with their search. "We're following up on more unknown blood types," he says. "There are probably on the order of 10 to 15 more of these unknown blood type systems where we know there is a problem but we don't know what the protein is that is causing the problem."

Although these other blood systems are very rare, "if you're that one individual, and you need a transfusion," Ballif says, "there's nothing more important for you to know."

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Source: http://www.eurekalert.org/pub_releases/2012-02/uov-bms022312.php

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